assay grade

Part 6 of 6 · What is left

The short list that survives review

After the claims fail and the levers are ranked, one dietary finding holds at the top grade. It is shorter than any food list for sale, and that is the finding.


This is the shortest chapter in the publication, and that is the finding, not an apology. When 2% of a field reaches high certainty, a long “what works” list would have to be manufactured.

The one top-grade dietary finding

AStrong evidence

A Mediterranean-style pattern lowers CRP and hs-CRP in adults with at least one chronic condition: −0.37 to −1.04 mg/L.

Three independent syntheses with different methods, databases and populations agree — including a 2026 meta-analysis of 33 randomised trials, n = 3,476.

Source: PMID 40657695, 39364652, 41211687

It has three explicit boundaries: the population is adults with an existing condition, the effect is largest where the markers start highest, and trials ran for weeks to months, not days. It does not lower TNF-α. Everything else in the chapter sits below it.

Open the chapter this comes from

Behind the paywall · part 6

The rest of the short list

  • The second tier: real effects at moderate certainty
  • The third tier: real, small, or contested
  • Doses and timeframes the trials actually used
  • Why the plan adds rather than eliminates, and the week that survives a bad week

$39

USD · one payment · no subscription

  • All nine chapters and all 26 graded claims
  • Web reader and a downloadable PDF
  • Every future correction and revision, included

Tick both boxes above to enable checkout.

Already purchased? Sign in with the purchase email

The short list that survives review — Assay Grade